The story takes place after the events of Stargate Atlantis and follows a group of characters who are stranded on an Ancient ship, the Destiny, which is on a course that will take it to a distant part of the universe. The main characters include Colonel Everett Young (Louis Ferreira), Lieutenant Matthew Scott (Peter Moo), Dr. Nicholas Rush (Robert Carlyle), and Dr. Samantha Carter (Claudia Black), among others.