The film is set in Nazi-occupied France during World War II. The story follows two main plotlines that eventually intersect. One plotline follows a young French Jewish woman, Shosanna Dreyfus (Mélanie Laurent), who escapes the massacre of her family and assumes a new identity. The other plotline follows a group of Jewish-American guerrilla warriors, known as "The Basterds," led by Lieutenant Aldo Raine (Brad Pitt), a tough and charismatic officer.

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The film is set in Nazi-occupied France during World War II. The story follows two main plotlines that eventually intersect. One plotline follows a young French Jewish woman, Shosanna Dreyfus (Mélanie Laurent), who escapes the massacre of her family and assumes a new identity. The other plotline follows a group of Jewish-American guerrilla warriors, known as "The Basterds," led by Lieutenant Aldo Raine (Brad Pitt), a tough and charismatic officer.