"Good Luck Chuck" revolves around Charlotte "Charlie" Wyman (Jessica Alba), a dentist who becomes a local hero after creating a series of hilarious and helpful dating tips for her younger brother, Danny (Bryan Hearne). As Charlie navigates her own love life, she meets Carter Farrell (Eric Christian Olsen), a charming and handsome stranger who becomes her love interest. The movie follows their journey as they navigate relationships, friendships, and the complexities of life.